AV MANAGEMENT ALGORITHM
Beating for the past two decades, SafeR™ has stood as the sole clinically proven solution to drastically reduce ventricular pacing, promoting natural AV conduction while ensuring long-term safety and efficacy for both you and your patients.1
SafeR™, powered by an exclusive technology, is a unique and versatile algorithm that offers you the freedom to create personalized therapies for both SND and AVB patients while safeguarding spontaneous AV conduction, leading to an extended device longevity.2
SIGNIFICANT REDUCTION OF V PACING COMPARED TO DDD
Excessive right ventricular pacing leads to increased risk of:
Atrial fibrillation3,4,5,6
Heart failure hospitalization3,6,7
Heart failure events and cardiac death8
SafeR™ is the only AV management solution proven to safely and effectively reduce Vp for both AV block and SND patients.
SafeR™ significantly reduces V pacing compared to DDD after 3 years follow-up – From the ANSWER STUDY
SafeR™ reduces unnecessary ventricular pacing to almost 0% for SND & AV block patients at rest & during exercise9
SAFE AND EFFECTIVE FOR ALL PACEMAKER PATIENTS
SafeR™ has been proven to be safe and effective for all pacemaker patients including those with AV Block or Sinus Node Disease.1
SafeR™ is activated by default 20 minutes after automatic detection of implantation.
SafeR™ is the only algorithm proven to effectively switch from AAI mode to DDD mode in all cases of AV block, including 1st degree AVB.1,2
SIGNIFICANT RISK REDUCTION OF AF AND HF HOSPITALIZATION
SafeR™ reduces the risk of first Atrial Fibrillation onset by 23% in ALL patients and by 35% in AV Block patients.1
SafeR™ showed a 51% risk reduction in experiencing cardiac death or HF hospitalization and 30% RR in experiencing cardiovascular hospitalizations for SND & AV block patients.1
EXTENDING DEVICE LONGEVITY
SafeR™ provides a greater longevity for intermittent AV Block patients as well as SND patients 2 – From the ANSWER SUB-STUDY:
With SafeR™ mode, 28% of women and 23% of men would avoid one pacemaker replacement when compare to DDD mode.
UNIQUE LONG PR MANAGEMENT
The SafeR™ algorithm is designed to reduce ventricular pacing while managing long PR at rest and during exercice. This means that SafeR™ switches from AAI mode to DDD mode in cases of long PR.
Personalised long PR parameters
The duration of the PR intervals is programmable (up to 500ms).
The settings can be adjusted to suit the patient’s activity both at rest and during exercise.
Intelligent management of Long PR interval to protect patients against deleterious effects of long PR
HEMODYNAMIC SUPPORT DURING EXERCISE
To avoid symptoms associated with any type of AV block during exercise, after 3 switches to DDD during exercise, pacing mode will remain in DDD until the end of the exercise:
FULL DIAGNOSTICS WITH EGMs
Records episodes of AV block with EGM A & V
Provides an accurate AVB degree diagnosis / classification allowing for optimized patient treatment
Data analysis and suggestions
SafeR™ pacing mode has been designed to promote the natural atrioventricular (AV) conduction and minimize the unnecessary right ventricular pacing.
SafeR™ provides AAI pacing while continuously monitoring AV conduction
It ensures DDD pacing when needed for ALL types of AV blocks, at rest and exercise
Switches back to AAI mode when needed
2 CONSECUTIVE BLOCKED ATRIAL EVENTS
AAI to DDD
3 BLOCKED ATRIAL EVENTS / 12 CONSECUTIVE CYCLES
AAI to DDD
6 CONSECUTIVE LONG PR INTERVALS
AAI to DDD
VENTRICULAR PAUSE OF 2.3 OR 4 SECONDS (PROGRAMMABLE)
AAI to DDD
12 CONSECUTIVE SENSED R WAVES
DDD to AAI
EVERY 100 PACED CYCLES
DDD to AAI
EVERY MORNING AT 8:00 AM
DDD to AAI
The ANSWER study is a randomized controlled multicentre trial assessing SafeR™ mode versus standard DDD mode in sinus node disease (SND) or AV block (AVB) patients. ANSWER enrolled 650 patients (52.0% SND, 48% AVB) at 43 European centers and randomized in SafeR™.
To gain deeper insights into Dr. Castro's professional perspective and witness the transformative capabilities of SafeR™
Listen to Dr. Daux's perspectives on SafeR™ technology and its potential impact on personalized patient care
Delve deeper into Dr. Catalan's insights and grasp the nuances of SafeR™ Technology
Listen to Prof. Oliveira's extensive experience and the profound impact of the SafeR™ algorithm
Join us as we celebrate 20 years of success and innovation of SafeR™ Technology
Disclaimer: The information on this website pertains to the SafeR™ algorithm for intelligent management of AV conduction. Please note that the products mentionned may not be approved for sale in certain regions, including the USA, Japan, and others. For details and regulatory information specific to your location, please contact your MicroPort CRM representative. It is essential to consult with your healthcare provider for personalized advice regarding the use of these products.
